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Tetanus toxin Rabbit Polyclonal Antibody (QYA10777)
產(chǎn)品名稱：破傷風(fēng)毒素兔多克隆抗體
貨號(hào)：QYA10777
主要參數(shù)
應(yīng)用：WB
適應(yīng)物種：Tetanus toxin
同種型：IgG
儲(chǔ)存溫度：-20℃
建議工作濃度：WB:1:2000-5000
特異性：抗體可以檢測(cè)內(nèi)源性和重組破傷風(fēng)毒素蛋白
背景
破傷風(fēng)毒素通過抑制神經(jīng)遞質(zhì)釋放發(fā)揮作用。它結(jié)合外周神經(jīng)元突觸，經(jīng)內(nèi)化后通過逆向運(yùn)輸沿軸突進(jìn)入脊髓，并可在突觸后與突觸前神經(jīng)元之間轉(zhuǎn)移。該毒素通過鋅內(nèi)肽酶活性催化突觸短蛋白-2（synaptobrevin-2）第76位谷氨酰胺與第77位苯丙氨酸之間的鍵水解，從而抑制神經(jīng)遞質(zhì)釋放。
注：本產(chǎn)品僅用于科研用途，不用于診斷和治療。
Product name: Tetanus toxin Rabbit Polyclonal Antibody
Cat: QYA10777
Main parameter
Applications: WB
Reactivity: Tetanus toxin
Isotype: IgG
Storage: -20℃
Recommended dilutions: WB:1:2000-5000
Specificity: Antibody can detects endogenous and recombinant Tetanus toxin protein.
Background
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
P.s. This product is only used for scientific research, not for diagnosis and treatment.
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