RanbP3 Mouse Monoclonal Antibody (QYA10771)
產品名稱：RanbP3鼠單克隆抗體
貨號：QYA10771
主要參數
應用：WB
適應物種：Human, Mouse, Rat
分子量：70, 90KD
同種型：IgG1
儲存溫度：-20℃
建議工作濃度：WB:1000-2000
特異性：抗體可以檢測內源性RanBP3蛋白
其他名稱：DKFZp58611520, RANB3
背景
作為XPO1/CRM1介導的核輸出的輔助因子，可能起輸出復合物支架蛋白作用。與XPO1/CRM1結合后，穩定XPO1/CRM1與結合物的蛋白互作。在缺乏Ran結合型GTP的情況下，可阻止XPO1/CRM1與核孔復合體結合。與CHC1/RCC1結合并增加其鳥嘌呤核苷酸交換活性。以Ran依賴性方式將XPO1/CRM1募集至CHC1/RCC1。通過與R-SMAD蛋白(SMAD2和SMAD3)相互作用并介導其核輸出，成為TGF-β信號通路的負調控因子。
注：本產品僅用于科研用途，不用于診斷和治療。
Product name: RanbP3 Mouse Monoclonal Antibody
Cat: QYA10771
Main parameter
Applications: Western Blot (WB)
Reactivity: Human, Mouse, Rat
Protein MW: 70, 90 KD
Isotype: IgG1
Storage: -20℃
Recommended dilutions: WB:1000-2000
Specificity: Antibody can detects endogenous RanBP3 protein.
Alternative Names: DKFZp58611520, RANB3
Background
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
P.s. This product is only used for scientific research, not for diagnosis and treatment.
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